Mosquero is located on State Highway 39. Interstate 25 can be accessed 52 miles to the west of Wagon Mound. Located on the high plains of northeastern New Mexico, Mosquero is the county seat of Harding County and is the smallest county seat in New Mexico. The original town-site plat was filed in July of 1908.   

Mosquero is conveniently located just a short drive from the breathtaking views of the New Mexico ranges of the Rocky Mountains.

Mosquero started as a settlement for the construction of the Dawson Railway in 1906. This stretch of rail was built from Tucumcari to the coal fields in Dawson by the Southern Pacific Railroad. The railroad was removed in 1964.

During the 1920s and 1930s dry ice was produced here because of the presence of the Bravo Dome, a huge carbon dioxide gas field beneath Harding County. 

The community also boosts of the rich tradition of cattle ranching being surrounded by some of the largest cattle ranches in existence today.

Today Mosquero is primarily a cattle ranching community with County Government located in the historic Court House at Third and Pine Streets.

Main street Mosquero recently had a face-lift, thanks to the effortts of the Mosquero School's Roundup Technology and the Digital Media Entrepreneur's Curriculum. They have plastered and painted the storefronts of several businesses and have painted murals depicting historical and community culture.